p53 post-translational modification: deregulated in tumorigenesis
The p53 tumor suppressor protein has well-established roles in monitoring various types of
stress signals by activating specific transcriptional targets that control cell cycle arrest and
apoptosis, although some activities are also mediated in a transcription-independent
manner. Here, we review the recent advances in our understanding of the wide spectrum of
post-translational modifications that act as epigenetic-like codes for modulating specific
functions of p53 in vivo and how deregulation of these modifications might contribute to …
stress signals by activating specific transcriptional targets that control cell cycle arrest and
apoptosis, although some activities are also mediated in a transcription-independent
manner. Here, we review the recent advances in our understanding of the wide spectrum of
post-translational modifications that act as epigenetic-like codes for modulating specific
functions of p53 in vivo and how deregulation of these modifications might contribute to …
The p53 tumor suppressor protein has well-established roles in monitoring various types of stress signals by activating specific transcriptional targets that control cell cycle arrest and apoptosis, although some activities are also mediated in a transcription-independent manner. Here, we review the recent advances in our understanding of the wide spectrum of post-translational modifications that act as epigenetic-like codes for modulating specific functions of p53 in vivo and how deregulation of these modifications might contribute to tumorigenesis. We also discuss future research priorities to further understand p53 post-translational modifications and the interpretation of genetic data in appreciation of the increasing evidence that p53 regulates cellular metabolism, autophagy and many unconventional tumor suppressor activities.
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