CD134 plays a crucial role in the pathogenesis of EAE and is upregulated in the CNS of patients with multiple sclerosis
S Carboni, F Aboul-Enein, C Waltzinger… - Journal of …, 2003 - Elsevier
We investigated the role of the CD134 (also named OX40) molecule in experimental allergic
encephalomyelitis (EAE) and multiple sclerosis (MS). We examined the susceptibility of
Cd134−/− mice to EAE, an autoimmune murine model that is dependent on infiltrating CD4+
T lymphocytes reactive to myelin proteins. EAE induced by myelin oligodendrocyte
glycoprotein (MOG) injection in Cd134−/− mice showed less severe clinical signs of disease
and markedly reduced inflammatory infiltrates within the central nervous system (CNS) …
encephalomyelitis (EAE) and multiple sclerosis (MS). We examined the susceptibility of
Cd134−/− mice to EAE, an autoimmune murine model that is dependent on infiltrating CD4+
T lymphocytes reactive to myelin proteins. EAE induced by myelin oligodendrocyte
glycoprotein (MOG) injection in Cd134−/− mice showed less severe clinical signs of disease
and markedly reduced inflammatory infiltrates within the central nervous system (CNS) …