Notch-independent functions of CSL
JE Johnson, RJ MacDonald - Current topics in developmental biology, 2011 - Elsevier
Notch-dependent CSL transcription complexes control essential biological processes such
as cell proliferation, differentiation, and cell-fate decisions in diverse developmental
systems. The orthologous proteins CBF1/Rbpj (mammalian), Su (H)(Drosophila), and Lag-1
(Caenorhabditis elegans) compose the CSL family of sequence-specific DNA-binding
transcription factors. The CSL proteins are best known for their role in canonical Notch
signaling. However, CSL factors also form transcription complexes that can function …
as cell proliferation, differentiation, and cell-fate decisions in diverse developmental
systems. The orthologous proteins CBF1/Rbpj (mammalian), Su (H)(Drosophila), and Lag-1
(Caenorhabditis elegans) compose the CSL family of sequence-specific DNA-binding
transcription factors. The CSL proteins are best known for their role in canonical Notch
signaling. However, CSL factors also form transcription complexes that can function …