Liver stem cells: experimental findings and implications for human liver disease
GK Michalopoulos, Z Khan - Gastroenterology, 2015 - Elsevier
GK Michalopoulos, Z Khan
Gastroenterology, 2015•ElsevierEvidence from human histopathology and experimental studies with rodents and zebrafish
has shown that hepatocytes and cholangiocytes may function as facultative stem cells for
each other in conditions of impaired regeneration. The interpretation of the findings derived
from these studies has generated considerable discussion and some controversies. This
review examines the evidence obtained from the different experimental models and
considers implications that these studies may have for human liver disease.
has shown that hepatocytes and cholangiocytes may function as facultative stem cells for
each other in conditions of impaired regeneration. The interpretation of the findings derived
from these studies has generated considerable discussion and some controversies. This
review examines the evidence obtained from the different experimental models and
considers implications that these studies may have for human liver disease.
Evidence from human histopathology and experimental studies with rodents and zebrafish has shown that hepatocytes and cholangiocytes may function as facultative stem cells for each other in conditions of impaired regeneration. The interpretation of the findings derived from these studies has generated considerable discussion and some controversies. This review examines the evidence obtained from the different experimental models and considers implications that these studies may have for human liver disease.
Elsevier