[HTML][HTML] A simple practice guide for dose conversion between animals and human

AB Nair, S Jacob - Journal of basic and clinical pharmacy, 2016 - ncbi.nlm.nih.gov
Journal of basic and clinical pharmacy, 2016ncbi.nlm.nih.gov
Understanding the concept of extrapolation of dose between species is important for
pharmaceutical researchers when initiating new animal or human experiments. Interspecies
allometric scaling for dose conversion from animal to human studies is one of the most
controversial areas in clinical pharmacology. Allometric approach considers the differences
in body surface area, which is associated with animal weight while extrapolating the doses
of therapeutic agents among the species. This review provides basic information about …
Abstract
Understanding the concept of extrapolation of dose between species is important for pharmaceutical researchers when initiating new animal or human experiments. Interspecies allometric scaling for dose conversion from animal to human studies is one of the most controversial areas in clinical pharmacology. Allometric approach considers the differences in body surface area, which is associated with animal weight while extrapolating the doses of therapeutic agents among the species. This review provides basic information about translation of doses between species and estimation of starting dose for clinical trials using allometric scaling. The method of calculation of injection volume for parenteral formulation based on human equivalent dose is also briefed.
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