[HTML][HTML] Lys-63-linked ubiquitination of γ-aminobutyric acid (GABA), type B1, at multiple sites by the E3 ligase mind bomb-2 targets GABAB receptors to lysosomal …
K Zemoura, C Trümpler, D Benke - Journal of Biological Chemistry, 2016 - ASBMB
GABA B receptors are heterodimeric G protein-coupled receptors, which control neuronal
excitability by mediating prolonged inhibition. The magnitude of GABA B receptor-mediated
inhibition essentially depends on the amount of receptors in the plasma membrane.
However, the factors regulating cell surface expression of GABA B receptors are poorly
characterized. Cell surface GABA B receptors are constitutively internalized and either
recycled to the plasma membrane or degraded in lysosomes. The signal that sorts GABA B …
excitability by mediating prolonged inhibition. The magnitude of GABA B receptor-mediated
inhibition essentially depends on the amount of receptors in the plasma membrane.
However, the factors regulating cell surface expression of GABA B receptors are poorly
characterized. Cell surface GABA B receptors are constitutively internalized and either
recycled to the plasma membrane or degraded in lysosomes. The signal that sorts GABA B …