Dysregulation of the epigenome in triple-negative breast cancers: basal-like and claudin-low breast cancers express aberrant DNA hypermethylation
A subset of human breast cancer cell lines exhibits aberrant DNA hypermethylation that is
characterized by hyperactivity of the DNA methyltransferase enzymes, overexpression of
DNMT3b, and concurrent methylation-dependent silencing of numerous epigenetic
biomarker genes. The objective of this study was to determine if this aberrant DNA
hypermethylation (i) is found in primary breast cancers,(ii) is associated with specific breast
cancer molecular subtypes, and (iii) influences patient outcomes. Analysis of epigenetic …
characterized by hyperactivity of the DNA methyltransferase enzymes, overexpression of
DNMT3b, and concurrent methylation-dependent silencing of numerous epigenetic
biomarker genes. The objective of this study was to determine if this aberrant DNA
hypermethylation (i) is found in primary breast cancers,(ii) is associated with specific breast
cancer molecular subtypes, and (iii) influences patient outcomes. Analysis of epigenetic …
