[HTML][HTML] Predicting response to epigenetic therapy

MB Treppendahl, LS Kristensen… - The Journal of clinical …, 2014 - Am Soc Clin Investig
MB Treppendahl, LS Kristensen, K Grønbæk
The Journal of clinical investigation, 2014Am Soc Clin Investig
Drugs targeting the epigenome are new promising cancer treatment modalities; however,
not all patients receive the same benefit from these drugs. In contrast to conventional
chemotherapy, responses may take several months after the initiation of treatment to occur.
Accordingly, identification of good pretreatment predictors of response is of great value.
Many clinical parameters and molecular targets have been tested in preclinical and clinical
studies with varying results, leaving room for optimization. Here we provide an overview of …
Drugs targeting the epigenome are new promising cancer treatment modalities; however, not all patients receive the same benefit from these drugs. In contrast to conventional chemotherapy, responses may take several months after the initiation of treatment to occur. Accordingly, identification of good pretreatment predictors of response is of great value. Many clinical parameters and molecular targets have been tested in preclinical and clinical studies with varying results, leaving room for optimization. Here we provide an overview of markers that may predict the efficacy of FDA- and EMA-approved epigenetic drugs.
The Journal of Clinical Investigation