Hypoxia and dysregulated metabolism are defining features of solid tumors. How cancer
cells adapt to low O 2 has been illuminated by numerous studies, with" reprogrammed"
metabolism being one of the most important mechanisms. This metabolic reprogramming
not only promotes cancer cell plasticity, but also provides novel insights for treatment
strategies. As the most studied O 2" sensor," hypoxia-inducible factor (HIF) is regarded as an
important regulator of hypoxia-induced transcriptional responses. This minireview will …