Muscle satellite cells are myogenic stem cells whose quiescence, activation, self-renewal,
and differentiation are influenced by oxygen supply, an environmental regulator of stem cell
activity. Accordingly, stem cell-specific oxygen signaling pathways precisely control the
balance between muscle growth and regeneration in response to oxygen fluctuations, and
hypoxia-inducible factors (HIFs) are central mediators of these cellular responses. However,
the in vivo roles of HIFs in quiescent satellite cells and activated satellite cells (myoblasts) …