The homeobox gene superfamily encodes transcription factors that act as master regulators
of development through their ability to activate or repress a diverse range of downstream
target genes. Numerous families exist within the homeobox gene superfamily, and are
classified on the basis of conservation of their homeodomains as well as additional motifs
that contribute to DNA binding and to interactions with other proteins. Members of one such
family, the Six family, form a transcriptional complex with Eya and Dach proteins, and …