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URL: http://scholar.google.com/scholar_lookup?title=The+canonical+Notch+signaling+pathway%3A+unfolding+the+activation+mechanism&year=2009&author=Kopan&journal=Cell&volume=137&issue=2&pages=216-233&doi=10.1016%2Fj.cell.2009.03.045&pmid=19379690