Glycoprotein 130 inhibitor ameliorates monocrotaline-induced pulmonary hypertension in rats

Z Huang, Z Liu, Q Luo, Z Zhao, Q Zhao, Y Zheng… - Canadian Journal of …, 2016 - Elsevier
Background Pulmonary arterial hypertension (PAH) is characterized by vasoconstriction,
vascular remodelling, and microthrombotic events. Inflammatory cytokine interleukin (IL-6)
may be a key factor in the development of PAH, and glycoprotein 130 (Gp130) is an
important signal-transducing subunit of IL-6. The aim of our study was to evaluate the
effectiveness of Gp130 inhibitor in reducing inflammation and ameliorating PAH-related
vascular remodelling in monocrotaline (MCT)-exposed rats. Methods Sprague-Dawley rats …