3-O-Formyl-20R, 21-epoxyresibufogenin suppresses IL-6–type cytokine actions by targeting the glycoprotein 130 subunit: Potential clinical implications

T Kino, TL Boos, A Sulima, EM Siegel, PW Gold… - Journal of allergy and …, 2007 - Elsevier
BACKGROUND: The multifunctional inflammatory cytokine IL-6 regulates the acute phase
reaction and plays central roles in the pathogenesis of chronic inflammatory disorders.
OBJECTIVES: Two small chemical compounds, 3-O-formyl-20R, 21-epoxyresibufogenin (TB-
2-081) and 3-O-formyl-20S, 21-epoxyresibufogenin (TB-2-082), known isolates from the
Chinese toad skin extract drug Ch'an Su, were synthesized and tested on the IL-6–induced
hepatic acute-phase reaction. METHODS: HepG2 cells or rat primary hepatocytes were …