[HTML][HTML] Stat3 recruitment by two distinct ligand-induced, tyrosine-phosphorylated docking sites in the interleukin-10 receptor intracellular domain
RM Weber-Nordt, JK Riley, AC Greenlund… - Journal of Biological …, 1996 - ASBMB
Recent work has shown that IL-10 induces activation of the JAK-STAT signaling pathway. To
define the mechanism underlying signal transducer and activator of transcription (STAT)
protein recruitment to the interleukin 10 (IL-10) receptor, the STAT proteins activated by IL-
10 in different cell populations were first defined using electrophoretic mobility shift assays.
In all cells tested, IL-10 activated Stat1 and Stat3 and induced the formation of three distinct
DNA binding complexes that contained different combinations of these two transcription …
define the mechanism underlying signal transducer and activator of transcription (STAT)
protein recruitment to the interleukin 10 (IL-10) receptor, the STAT proteins activated by IL-
10 in different cell populations were first defined using electrophoretic mobility shift assays.
In all cells tested, IL-10 activated Stat1 and Stat3 and induced the formation of three distinct
DNA binding complexes that contained different combinations of these two transcription …
