[HTML][HTML] Insights into integrin-ligand binding and activation from the first crystal structure
MJ Humphries - Arthritis Research & Therapy, 2002 - Springer
Arthritis Research & Therapy, 2002•Springer
Chapter summary Integrin receptors transduce bidirectional signals between extracellular
adhesion molecules and intracellular cytoskeletal and signalling molecules. The structural
basis of integrin signalling is unknown, but the recent publication of the first crystal structure
of the extracellular domain of integrin αVβ3 has provided a number of insights. In this review,
previous structure–function analyses of integrins that have employed biochemical and
molecular biological approaches are placed in the context of the crystal structure, and novel …
adhesion molecules and intracellular cytoskeletal and signalling molecules. The structural
basis of integrin signalling is unknown, but the recent publication of the first crystal structure
of the extracellular domain of integrin αVβ3 has provided a number of insights. In this review,
previous structure–function analyses of integrins that have employed biochemical and
molecular biological approaches are placed in the context of the crystal structure, and novel …
Chapter summary
Integrin receptors transduce bidirectional signals between extracellular adhesion molecules and intracellular cytoskeletal and signalling molecules. The structural basis of integrin signalling is unknown, but the recent publication of the first crystal structure of the extracellular domain of integrin αVβ3 has provided a number of insights. In this review, previous structure–function analyses of integrins that have employed biochemical and molecular biological approaches are placed in the context of the crystal structure, and novel routes to the development of integrin antagonists are discussed.
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