[HTML][HTML] Shedding of endogenous interleukin-6 receptor (IL-6R) is governed by a disintegrin and metalloproteinase (ADAM) proteases while a full-length IL-6R isoform …
N Schumacher, D Meyer, A Mauermann… - Journal of Biological …, 2015 - ASBMB
Generation of the soluble interleukin-6 receptor (sIL-6R) is a prerequisite for pathogenic IL-6
trans-signaling, which constitutes a distinct signaling pathway of the pleiotropic cytokine
interleukin-6 (IL-6). Although in vitro experiments using ectopically overexpressed IL-6R and
candidate proteases revealed major roles for the metalloproteinases ADAM10 and ADAM17
in IL-6R shedding, the identity of the protease (s) cleaving IL-6R in more physiological
settings, or even in vivo, remains unknown. By taking advantage of specific pharmacological …
trans-signaling, which constitutes a distinct signaling pathway of the pleiotropic cytokine
interleukin-6 (IL-6). Although in vitro experiments using ectopically overexpressed IL-6R and
candidate proteases revealed major roles for the metalloproteinases ADAM10 and ADAM17
in IL-6R shedding, the identity of the protease (s) cleaving IL-6R in more physiological
settings, or even in vivo, remains unknown. By taking advantage of specific pharmacological …