A new murine model of accelerated senescence
T Takeda, M Hosokawa, S Takeshita, M Irino… - Mechanisms of ageing …, 1981 - Elsevier
Five senescence-prone series of mice (P-1, P-2, P-3, P-4 and P-5) and three senescence-
resistant series (R-1, R-2 and R-3) were obtained by continuous brother-sister breeding from
five original litters of AKR mice with severe deterioration, and the three original litters of AKR
mice with normal aging, respectively. A grading score system was adopted to evaluate the
degree of senescence of these mice and a steady and irreversible increase in this grading
score was seen with advancing age in both the R and P series. The high grading score in …
resistant series (R-1, R-2 and R-3) were obtained by continuous brother-sister breeding from
five original litters of AKR mice with severe deterioration, and the three original litters of AKR
mice with normal aging, respectively. A grading score system was adopted to evaluate the
degree of senescence of these mice and a steady and irreversible increase in this grading
score was seen with advancing age in both the R and P series. The high grading score in …