Nociception and inflammatory hyperalgesia evaluated in rodents using infrared laser stimulation after Trpv1 gene knockout or resiniferatoxin lesion

K Mitchell, EE Lebovitz, JM Keller, AJ Mannes… - PAINŽ, 2014 - Elsevier
TRPV1 is expressed in a subpopulation of myelinated Aδ and unmyelinated C-fibers.
TRPV1+ fibers are essential for the transmission of nociceptive thermal stimuli and for the
establishment and maintenance of inflammatory hyperalgesia. We have previously shown
that high-power, short-duration pulses from an infrared diode laser are capable of
predominantly activating cutaneous TRPV1+ Aδ-fibers. Here we show that stimulating either
subtype of TRPV1+ fiber in the paw during carrageenan-induced inflammation or following …