Pharmacologically induced selective degeneration of chemosensitive primary sensory neurones

G Jancso, E Kiraly, A JANCSÓ-GÁBOR - Nature, 1977 - nature.com
G Jancso, E Kiraly, A JANCSÓ-GÁBOR
Nature, 1977nature.com
PHARMACOLOGICALLY evoked selective degeneration of neurones with a specific function
or functioning with known transmitter substances, has been reported only in the
monoaminergic neurone systems1, 2. We report here that selective degeneration of
neurones with a highly specific function can be produced by chemical agents in the
somatosensory system as well. Capsaicin given to newborn rats induces selective
degeneration of a distinct population of primary sensory neurones involved in mediation of …
Abstract
PHARMACOLOGICALLY evoked selective degeneration of neurones with a specific function or functioning with known transmitter substances, has been reported only in the monoaminergic neurone systems1,2. We report here that selective degeneration of neurones with a highly specific function can be produced by chemical agents in the somatosensory system as well. Capsaicin given to newborn rats induces selective degeneration of a distinct population of primary sensory neurones involved in mediation of chemogenic pain.
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