Background Resiniferatoxin is a potent capsaicin analog. Intrathecal administration leads to
selective, prolonged opening of the transient receptor potential V1 ion channel, which is
localized mainly to C-fiber primary afferent nociceptive sensory neurons. Following work in
laboratory animals, the authors explored the use of intrathecal resiniferatoxin to control
spontaneous bone cancer pain in companion (pet) dogs. Methods Normal canine
population: Behavioral testing was performed to establish baseline paw withdrawal latency; …