[HTML][HTML] Differential effects of scavenger receptor BI deficiency on lipid metabolism in cells of the arterial wall and in the liver
M Van Eck, J Twisk, M Hoekstra, BT Van Rij… - Journal of Biological …, 2003 - ASBMB
Scavenger receptor class B, type I (SRBI) is a key regulator of high density lipoprotein (HDL)
metabolism. It facilitates the efflux of cholesterol from cells in peripheral tissues to HDL and
mediates the selective uptake of cholesteryl esters from HDL in the liver. We investigated the
effects of SRBI deficiency in the arterial wall and in the liver using SRBI-deficient mice and
wild-type littermates fed a Western-type diet. The SRBI-deficient mice showed massive
accumulation of cholesterol-rich HDL in the circulation, reflecting impaired delivery to the …
metabolism. It facilitates the efflux of cholesterol from cells in peripheral tissues to HDL and
mediates the selective uptake of cholesteryl esters from HDL in the liver. We investigated the
effects of SRBI deficiency in the arterial wall and in the liver using SRBI-deficient mice and
wild-type littermates fed a Western-type diet. The SRBI-deficient mice showed massive
accumulation of cholesterol-rich HDL in the circulation, reflecting impaired delivery to the …