[HTML][HTML] High density lipoprotein metabolism in low density lipoprotein receptor-deficient mice1 [S]
The LDL receptor (LDLR) and scavenger receptor class B type I (SR-BI) play physiological
roles in LDL and HDL metabolism in vivo. In this study, we explored HDL metabolism in
LDLR-deficient mice in comparison with WT littermates. Murine HDL was radiolabeled in the
protein (125 I) and in the cholesteryl ester (CE) moiety ([3 H]). The metabolism of 125 I-/[3 H]
HDL was investigated in plasma and in tissues of mice and in murine hepatocytes. In WT
mice, liver and adrenals selectively take up HDL-associated CE ([3 H]). In contrast, in …
roles in LDL and HDL metabolism in vivo. In this study, we explored HDL metabolism in
LDLR-deficient mice in comparison with WT littermates. Murine HDL was radiolabeled in the
protein (125 I) and in the cholesteryl ester (CE) moiety ([3 H]). The metabolism of 125 I-/[3 H]
HDL was investigated in plasma and in tissues of mice and in murine hepatocytes. In WT
mice, liver and adrenals selectively take up HDL-associated CE ([3 H]). In contrast, in …