[HTML][HTML] Scavenger receptor class B type I is solely responsible for the selective uptake of cholesteryl esters from HDL by the liver and the adrenals in mice
R Out, M Hoekstra, JAA Spijkers, JK Kruijt… - Journal of lipid …, 2004 - ASBMB
Scavenger receptor class B type I (SR-BI) has been identified as a functional HDL binding
protein that can mediate the selective uptake of cholesteryl ester (CE) from HDL. To quantify
the in vivo role of SR-BI in the process of selective uptake, HDL was labeled with cholesteryl
ether ([3 H] CEt-HDL) and 125 I-tyramine cellobiose ([125 I] TC-HDL) and injected into SR-BI
knockout (KO) and wild-type (WT) mice. In SR-BI KO mice, the clearance of HDL-CE from the
blood circulation was greatly diminished (0.043±0.004 pools/h for SR-BI KO mice vs …
protein that can mediate the selective uptake of cholesteryl ester (CE) from HDL. To quantify
the in vivo role of SR-BI in the process of selective uptake, HDL was labeled with cholesteryl
ether ([3 H] CEt-HDL) and 125 I-tyramine cellobiose ([125 I] TC-HDL) and injected into SR-BI
knockout (KO) and wild-type (WT) mice. In SR-BI KO mice, the clearance of HDL-CE from the
blood circulation was greatly diminished (0.043±0.004 pools/h for SR-BI KO mice vs …