Ribonuclease inhibitor: structure and function
KA Dickson, MC Haigis, RT Raines - Progress in nucleic acid research and …, 2005 - Elsevier
Publisher Summary The mammalian ribonuclease inhibitor (RI) is a 50‐kDa cytosolic protein
that binds to pancreatic‐type ribonucleases with femtomolar affinity and renders them
inactive. The biological role of RI is not known in its entirety. The ribonucleases recognized
by RI are secreted proteins, whereas RI resides exclusively in the cytosol. Nevertheless, RI
affinity has been shown to be the primary determinant of ribonuclease cytotoxicity: Only
ribonucleases that evade RI can kill a cell. In addition, the complex of RI with human …
that binds to pancreatic‐type ribonucleases with femtomolar affinity and renders them
inactive. The biological role of RI is not known in its entirety. The ribonucleases recognized
by RI are secreted proteins, whereas RI resides exclusively in the cytosol. Nevertheless, RI
affinity has been shown to be the primary determinant of ribonuclease cytotoxicity: Only
ribonucleases that evade RI can kill a cell. In addition, the complex of RI with human …