[HTML][HTML] A compendium of genome-wide hematopoietic transcription factor maps supports the identification of gene regulatory control mechanisms
OBJECTIVE: Key regulators of blood stem cell differentiation into the various mature
hematopoietic lineages are commonly encoded by transcription factor genes. Elucidation of
transcriptional regulatory mechanisms therefore holds great promise in advancing our
understanding of both normal and malignant hematopoiesis. Recent technological
advances have enabled the generation of genome-wide transcription factor binding maps
using chromatin immunoprecipitation coupled with high-throughput sequencing (ChIP-Seq) …
hematopoietic lineages are commonly encoded by transcription factor genes. Elucidation of
transcriptional regulatory mechanisms therefore holds great promise in advancing our
understanding of both normal and malignant hematopoiesis. Recent technological
advances have enabled the generation of genome-wide transcription factor binding maps
using chromatin immunoprecipitation coupled with high-throughput sequencing (ChIP-Seq) …