[HTML][HTML] The cytosolic ribonuclease inhibitor contributes to intracellular redox homeostasis
DM Monti, NM Gesualdi, J Matoušek, F Esposito… - FEBS letters, 2007 - Elsevier
DM Monti, NM Gesualdi, J Matoušek, F Esposito, G D'Alessio
FEBS letters, 2007•ElsevierThe hypothesis that the cytosolic RNase inhibitor (cRI) has a role in the protection of the
cellular redox homeostasis was investigated testing the effects of oxidants and anti-oxidants
on normal, primary endothelial HUVE cells, and malignant HeLa cells, before and after their
engineering into cRI-deprived cells. We found that cRI plays an important, possibly a key,
physiological role in the protection of cells from redox stress, as demonstrated by decreased
GSH levels as well as increased oxidant-induced DNA damage in cRI deprived cells.
cellular redox homeostasis was investigated testing the effects of oxidants and anti-oxidants
on normal, primary endothelial HUVE cells, and malignant HeLa cells, before and after their
engineering into cRI-deprived cells. We found that cRI plays an important, possibly a key,
physiological role in the protection of cells from redox stress, as demonstrated by decreased
GSH levels as well as increased oxidant-induced DNA damage in cRI deprived cells.
The hypothesis that the cytosolic RNase inhibitor (cRI) has a role in the protection of the cellular redox homeostasis was investigated testing the effects of oxidants and anti-oxidants on normal, primary endothelial HUVE cells, and malignant HeLa cells, before and after their engineering into cRI-deprived cells. We found that cRI plays an important, possibly a key, physiological role in the protection of cells from redox stress, as demonstrated by decreased GSH levels as well as increased oxidant-induced DNA damage in cRI deprived cells.
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