Adoptive transfer of cloned melanoma-reactive T lymphocytes for the treatment of patients with metastatic melanoma
ME Dudley, J Wunderlich, MI Nishimura… - Journal of …, 2001 - journals.lww.com
This report describes a phase I study of the adoptive transfer of cloned melanoma antigen–
specific T lymphocytes for therapy of patients with advanced melanoma. Clones were
derived from peripheral blood lymphocytes or tumor-infiltrating lymphocytes of patients who
had received prior immunization with the melanoma-associated antigen, gp100. In response
to its cognate antigen, each clone used for treatment secreted large amounts of interferon-γ
and granulocyte-macrophage colony-stimulating factor, lesser amounts of interleukin (IL)-2 …
specific T lymphocytes for therapy of patients with advanced melanoma. Clones were
derived from peripheral blood lymphocytes or tumor-infiltrating lymphocytes of patients who
had received prior immunization with the melanoma-associated antigen, gp100. In response
to its cognate antigen, each clone used for treatment secreted large amounts of interferon-γ
and granulocyte-macrophage colony-stimulating factor, lesser amounts of interleukin (IL)-2 …