[HTML][HTML] Experimental study of the relationship between Plasmodium gametocyte density and infection success in mosquitoes; implications for the evaluation of …

DF Da, TS Churcher, RS Yerbanga, B Yaméogo… - Experimental …, 2015 - Elsevier
The evaluation of transmission reducing interventions (TRI) to control malaria widely uses
membrane feeding assays. In such assays, the intensity of Plasmodium infection in the
vector might affect the measured efficacy of the candidates to block transmission.
Gametocyte density in the host blood is a determinant of the infection success in the
mosquito, however, uncertain estimates of parasite densities and intrinsic characteristics of
the infected blood can induce variability. To reduce this variation, a feasible method is to …