Polymorphisms in the genes encoding chemokine receptor 5, interleukin-10, and monocyte chemoattractant protein 1 contribute to cytomegalovirus reactivation and …

J Loeffler, M Steffens, EM Arlt, MR Toliat… - Journal of clinical …, 2006 - Am Soc Microbiol
J Loeffler, M Steffens, EM Arlt, MR Toliat, M Mezger, A Suk, TF Wienker, H Hebart
Journal of clinical microbiology, 2006Am Soc Microbiol
We analyzed 90 polymorphisms in 17 genes related to immune function for association with
human cytomegalovirus (HCMV) reactivation and disease in patients after allogeneic stem
cell transplantation. We found relevant markers (i) in CCR5 and IL-10 genes conferring a
higher risk for the development of HCMV disease and (ii) in the MCP1 gene associated with
HCMV reactivation. Testing of high-risk patients for the presence of these single-nucleotide
polymorphisms might be useful for individualizing antiviral prophylaxis.
Abstract
We analyzed 90 polymorphisms in 17 genes related to immune function for association with human cytomegalovirus (HCMV) reactivation and disease in patients after allogeneic stem cell transplantation. We found relevant markers (i) in CCR5 and IL-10 genes conferring a higher risk for the development of HCMV disease and (ii) in the MCP1 gene associated with HCMV reactivation. Testing of high-risk patients for the presence of these single-nucleotide polymorphisms might be useful for individualizing antiviral prophylaxis.
American Society for Microbiology