Can immune-related genotypes illuminate the immunopathogenesis of cytomegalovirus disease in human immunodeficiency virus–infected patients?

JS Affandi, ZKA Aghafar, B Rodriguez, MM Lederman… - Human immunology, 2012 - Elsevier
Most human immunodeficiency virus (HIV) patients are seropositive for cytomegalovirus
(CMV) but a smaller proportion experience end-organ disease. This observation may reflect
variations in genes affecting inflammatory and natural killer cell responses. DNA samples
were collected from 240 HIV-infected patients followed at the University Hospitals/Case
Medical Center (Cleveland, OH) between 1993 and 2008. Seventy-eight patients (African
Americans= 41, Caucasians= 37) experienced CMV disease. Genotypes were determined …