[HTML][HTML] Gab-1-mediated IGF-1 signaling in IRS-1-deficient 3T3 fibroblasts
The insulin receptor substrate (IRS) family of proteins mediate a variety of intracellular
signaling events by serving as signaling platforms downstream of several receptor tyrosine
kinases including the insulin and insulin-like growth factor-1 (IGF-1) receptors. Recently,
several new members of this family have been identified including IRS-3, IRS-4, and growth
factor receptor-binding protein 2-associated binder-1 (Gab-1). 3T3 cell lines derived from
IRS-1-deficient embryos exhibit a 70–80% reduction in IGF-1-stimulated S-phase entry and …
signaling events by serving as signaling platforms downstream of several receptor tyrosine
kinases including the insulin and insulin-like growth factor-1 (IGF-1) receptors. Recently,
several new members of this family have been identified including IRS-3, IRS-4, and growth
factor receptor-binding protein 2-associated binder-1 (Gab-1). 3T3 cell lines derived from
IRS-1-deficient embryos exhibit a 70–80% reduction in IGF-1-stimulated S-phase entry and …