[HTML][HTML] An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1
The mammalian target of rapamycin (mTOR) kinase is the catalytic subunit of two
functionally distinct complexes, mTORC1 and mTORC2, that coordinately promote cell
growth, proliferation, and survival. Rapamycin is a potent allosteric mTORC1 inhibitor with
clinical applications as an immunosuppressant and anti-cancer agent. Here we find that
Torin1, a highly potent and selective ATP-competitive mTOR inhibitor that directly inhibits
both complexes, impairs cell growth and proliferation to a far greater degree than rapamycin …
functionally distinct complexes, mTORC1 and mTORC2, that coordinately promote cell
growth, proliferation, and survival. Rapamycin is a potent allosteric mTORC1 inhibitor with
clinical applications as an immunosuppressant and anti-cancer agent. Here we find that
Torin1, a highly potent and selective ATP-competitive mTOR inhibitor that directly inhibits
both complexes, impairs cell growth and proliferation to a far greater degree than rapamycin …