[PDF][PDF] Effects of aging on activities of mitochondrial electron transport chain complexes and oxidative damage in rat heart

Z Tatarkova, S Kuka, P Racay, J Lehotský… - Physiological …, 2011 - researchgate.net
Z Tatarkova, S Kuka, P Racay, J Lehotský, D Dobrota, D Mistuna, P Kaplán
Physiological research, 2011researchgate.net
Mitochondrial dysfunction and accumulation of oxidative damage have been implicated to
be the major factors of aging. However, data on age-related changes in activities of
mitochondrial electron transport chain (ETC) complexes remain controversial and molecular
mechanisms responsible for ETC dysfunction are still largely unknown. In this study, we
examined the effect of aging on activities of ETC complexes and oxidative damage to
proteins and lipids in cardiac mitochondria from adult (6-month-old), old (15-month-old) and …
Summary
Mitochondrial dysfunction and accumulation of oxidative damage have been implicated to be the major factors of aging. However, data on age-related changes in activities of mitochondrial electron transport chain (ETC) complexes remain controversial and molecular mechanisms responsible for ETC dysfunction are still largely unknown. In this study, we examined the effect of aging on activities of ETC complexes and oxidative damage to proteins and lipids in cardiac mitochondria from adult (6-month-old), old (15-month-old) and senescent (26-month-old) rats. ETC complexes I-
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