Sarcalumenin plays a critical role in age-related cardiac dysfunction due to decreases in SERCA2a expression and activity
Q Jiao, H Takeshima, Y Ishikawa, S Minamisawa - Cell Calcium, 2012 - Elsevier
Impaired Ca2+ reuptake into the sarcoplasmic reticulum (SR) underlies a primary
pathogenesis of heart failure in the aging heart. Sarcalumenin (SAR), a Ca2+-binding
glycoprotein located in the longitudinal SR, regulates Ca2+ reuptake by interacting with SR
Ca2+-ATPase (SERCA). Here we found that the expression levels of both SAR and
SERCA2 proteins were significantly downregulated in senescent wild-type mice (18-month
old) and that downregulation of SAR protein preceded downregulation of SERCA2 protein …
pathogenesis of heart failure in the aging heart. Sarcalumenin (SAR), a Ca2+-binding
glycoprotein located in the longitudinal SR, regulates Ca2+ reuptake by interacting with SR
Ca2+-ATPase (SERCA). Here we found that the expression levels of both SAR and
SERCA2 proteins were significantly downregulated in senescent wild-type mice (18-month
old) and that downregulation of SAR protein preceded downregulation of SERCA2 protein …
