[HTML][HTML] Pathophysiology of osteoarthritis

J Martel-Pelletier - Osteoarthritis and cartilage, 2004 - Elsevier
Osteoarthritis (OA) is characterized by a degeneration of articular cartilage, in which the
breakdown leads to matrix fibrillation, fissure appearance, gross ulceration, and fullthickness
loss of the joint surface. This is accompanied by hypertrophic bone changes with osteophyte
formation and subchondral bone plate thickening. At the clinical stage of the disease,
change in the synovial membrane is also found together with an inflammatory reaction. The
principal factors described are involved in two of the major tissues (these being the cartilage …

[PDF][PDF] Pathophysiology of osteoarthritis

J Martel-Pelletier - Osteoarthritis and cartilage, 1999 - core.ac.uk
Although cartilage degeneration characterizes human osteoarthritis (OA), changes also
involve the participation of the synovial membrane and the subchondral bone. In this review,
attention will be focused on current knowledge of the major factors participating in the
degeneration of OA articular joints tissues. Firstly, we will address the biochemical agents
involved in the destruction of cartilage and synovial membrane. This will be followed by a
brief survey of the most important modulatory factors of proinflammatory cytokines as well as …