[HTML][HTML] Interaction between the CD8 coreceptor and major histocompatibility complex class I stabilizes T cell receptor-antigen complexes at the cell surface

L Wooldridge, HA van den Berg, M Glick… - Journal of Biological …, 2005 - ASBMB
The off-rate (k off) of the T cell receptor (TCR)/peptide-major histocompatibility complex class
I (pMHCI) interaction, and hence its half-life, is the principal kinetic feature that determines
the biological outcome of TCR ligation. However, it is unclear whether the CD8 coreceptor,
which binds pMHCI at a distinct site, influences this parameter. Although biophysical studies
with soluble proteins show that TCR and CD8 do not bind cooperatively to pMHCI,
accumulating evidence suggests that TCR associates with CD8 on the T cell surface. Here …