[CITATION][C] Comparative penetration of glycopyrrolate and atropine across the blood—brain and placental barriers in anesthetized dogs
AG Proakis, GB Harris - The Journal of the American Society of …, 1978 - pubs.asahq.org
The levels of" C-glycopyrrolate, a quaternary ammonium anticholinergic agent, appearing in
cerebrospinal fluid (CSF) and serum (S) following a single intravenous dose of 0.1 mg/kg
were determined in mongrel dogs during barbiturate anesthesia and compared with levels
reached in dogs treated with similar doses of" H-atropine. Presence of each anticholinergic
drug in the peripheral circulation was confirmed by antagonism of the depressor résponse to
intravenously administered acetylcholine. Ten minutes after drug injection, CSF levels of* H …
cerebrospinal fluid (CSF) and serum (S) following a single intravenous dose of 0.1 mg/kg
were determined in mongrel dogs during barbiturate anesthesia and compared with levels
reached in dogs treated with similar doses of" H-atropine. Presence of each anticholinergic
drug in the peripheral circulation was confirmed by antagonism of the depressor résponse to
intravenously administered acetylcholine. Ten minutes after drug injection, CSF levels of* H …