Biomarker surrogates do not accurately predict sputum eosinophil and neutrophil percentages in asthmatic subjects
AT Hastie, WC Moore, H Li, BM Rector… - Journal of allergy and …, 2013 - Elsevier
Background Sputum eosinophil percentages are a strong predictor of airway inflammation
and exacerbations and aid asthma management, whereas sputum neutrophil percentages
indicate a different severe asthma phenotype that is potentially less responsive to TH 2-
targeted therapy. Variables, such as blood eosinophil counts, total IgE levels, fraction of
exhaled nitric oxide (F eno) levels, or FEV 1 percent predicted, might predict airway
eosinophil percentages, whereas age, FEV 1 percent predicted, or blood neutrophil counts …
and exacerbations and aid asthma management, whereas sputum neutrophil percentages
indicate a different severe asthma phenotype that is potentially less responsive to TH 2-
targeted therapy. Variables, such as blood eosinophil counts, total IgE levels, fraction of
exhaled nitric oxide (F eno) levels, or FEV 1 percent predicted, might predict airway
eosinophil percentages, whereas age, FEV 1 percent predicted, or blood neutrophil counts …