Skin is the most frequent target of drug reactions that are reported, may be because they are
easily detected. Most (probably more than 90%) are related to drug hypersensitivity, ie an
individually tailored, unexpected effect mediated by a drug specific activation of the immune
response. The clinical presentation of “drug eruptions” is highly variable, from the most
common transient and benign erythema that occurs 6–9 days after the introduction of a new
drug in 1 to 3% of users to the most severe forms, that fortunately affect less than 1/10,000 …