The predominant drug-specific T-cell population may switch from cytotoxic T cells to regulatory T cells during the course of anticonvulsant-induced hypersensitivity
T Hanafusa, H Azukizawa, S Matsumura… - Journal of dermatological …, 2012 - Elsevier
BACKGROUND: Delayed hypersensitivity is responsible for severe cutaneous adverse drug
reactions (cADRs), especially in Stevens-Johnson syndrome (SJS), toxic epidermal
necrolysis, and drug-induced hypersensitivity syndrome (DIHS)(also known as drug rash
with eosinophilia and systemic symptoms [DRESS] syndrome). The drug-induced
lymphocyte stimulation test (DLST), or lymphocyte transformation test (LTT), is used to
identify the culprit drug in severe cADR cases. OBJECTIVE: The aim of this study was to …
reactions (cADRs), especially in Stevens-Johnson syndrome (SJS), toxic epidermal
necrolysis, and drug-induced hypersensitivity syndrome (DIHS)(also known as drug rash
with eosinophilia and systemic symptoms [DRESS] syndrome). The drug-induced
lymphocyte stimulation test (DLST), or lymphocyte transformation test (LTT), is used to
identify the culprit drug in severe cADR cases. OBJECTIVE: The aim of this study was to …