Shared and restricted T-cell receptor use is crucial for carbamazepine-induced Stevens-Johnson syndrome
BACKGROUND: Stevens-Johnson syndrome (SJS) and its related disease, toxic epidermal
necrolysis (TEN), are life-threatening drug hypersensitivities with robust immune responses
to drugs. Despite the strong HLA predisposition to drug hypersensitivities, such as HLA-B∗
1502 to carbamazepine (CBZ)–induced SJS/TEN, it remains unknown whether particular T-
cell receptors (TCRs) participate in recognition of small drug/peptide–HLA complexes.
OBJECTIVE: Using the strong HLA predisposition in patients with CBZ-induced SJS/TEN as …
necrolysis (TEN), are life-threatening drug hypersensitivities with robust immune responses
to drugs. Despite the strong HLA predisposition to drug hypersensitivities, such as HLA-B∗
1502 to carbamazepine (CBZ)–induced SJS/TEN, it remains unknown whether particular T-
cell receptors (TCRs) participate in recognition of small drug/peptide–HLA complexes.
OBJECTIVE: Using the strong HLA predisposition in patients with CBZ-induced SJS/TEN as …