Insulin-induced augmentation of lymphocyte-mediated cytotoxicity
TB Strom, RA Bear, CB Carpenter - Science, 1975 - science.org
TB Strom, RA Bear, CB Carpenter
Science, 1975•science.orgPhysiologic concentrations of insulin enhance the ability of cytotoxic lymphocytes to injure
target cells. The effect of insulin closely resembles the action of cholinomimetics and
guanosine 3′, 5′-monophosphate upon this system. Since both insulin and
cholinomimetics elevate intracellular concentrations of guanosine 3′, 5′-monophosphate,
a common mode of action is suggested.
target cells. The effect of insulin closely resembles the action of cholinomimetics and
guanosine 3′, 5′-monophosphate upon this system. Since both insulin and
cholinomimetics elevate intracellular concentrations of guanosine 3′, 5′-monophosphate,
a common mode of action is suggested.
Physiologic concentrations of insulin enhance the ability of cytotoxic lymphocytes to injure target cells. The effect of insulin closely resembles the action of cholinomimetics and guanosine 3′,5′-monophosphate upon this system. Since both insulin and cholinomimetics elevate intracellular concentrations of guanosine 3′,5′-monophosphate, a common mode of action is suggested.
AAAS