[HTML][HTML] Immobilized transition metal ions stimulate contact activation and drive factor XII‐mediated coagulation
NJ Mutch, EK Waters, JH Morrissey - Journal of Thrombosis and …, 2012 - Elsevier
Background: Upon contact with an appropriate surface, factor XII (FXII) undergoes
autoactivation or cleavage by kallikrein. Zn 2+ is known to facilitate binding of FXII and the
cofactor, high molecular weight kininogen (HK), to anionic surfaces. Objectives: To
investigate whether transition metal ions immobilized on liposome surfaces can initiate
coagulation via the contact pathway. Methods and results: Liposomes containing a metal ion‐
chelating lipid, 1, 2‐dioleoyl‐sn‐glycero‐3‐{(N [5‐amino‐1‐carboxypentyl] iminodiacetic …
autoactivation or cleavage by kallikrein. Zn 2+ is known to facilitate binding of FXII and the
cofactor, high molecular weight kininogen (HK), to anionic surfaces. Objectives: To
investigate whether transition metal ions immobilized on liposome surfaces can initiate
coagulation via the contact pathway. Methods and results: Liposomes containing a metal ion‐
chelating lipid, 1, 2‐dioleoyl‐sn‐glycero‐3‐{(N [5‐amino‐1‐carboxypentyl] iminodiacetic …