Development of potent, allosteric dual Akt1 and Akt2 inhibitors with improved physical properties and cell activity

Z Zhao, RG Robinson, SF Barnett… - Bioorganic & medicinal …, 2008 - Elsevier
Z Zhao, RG Robinson, SF Barnett, D Defeo-Jones, RE Jones, GD Hartman, HE Huber
Bioorganic & medicinal chemistry letters, 2008Elsevier
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Elsevier Bioorganic & Medicinal Chemistry Letters Volume 18, Issue 1, 1 January 2008, Pages
49-53 Bioorganic & Medicinal Chemistry Letters Development of potent, allosteric dual Akt1
and Akt2 inhibitors with improved physical properties and cell activity Author links open overlay …
This letter describes the development of potent, allosteric dual Akt1 and Akt2 inhibitors with improved aqueous solubility (∼18mg/mL) that translates into enhanced cell activity and caspase-3 induction.
Elsevier