Angiogenesis, a complex process tightly controlled by several molecules including vascular
endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) along with their
receptors, plays a major role in the growth and metastasis of solid tumors. The expression
and production of VEGF and bFGF have been documented in numerous solid tumors and
hematopoietic neoplasms. Having recently shown increased expression of cellular VEGF in
the leukemic cells of patients with chronic lymphocytic leukemia (CLL) we decided to …