Costameres are cellular sites of mechanotransduction in heart and skeletal muscle where
dystrophin and its membrane-spanning partner dystroglycan distribute intracellular
contractile forces into the surrounding extracellular matrix. Resolution of a functional
costamere interactome is still limited but likely to be critical for understanding forms of
muscular dystrophy and cardiomyopathy. Dystrophin binds a set of membrane-associated
proteins (the dystrophin-glycoprotein complex) as well as γ-actin and microtubules and also …