[HTML][HTML] Fibrillogenic amylin evokes islet β-cell apoptosis through linked activation of a caspase cascade and JNK1
Fibrillogenic human amylin elicits pancreatic β-cell apoptosis that may contribute to
development of type-2 diabetes. Here, we demonstrated that activation of a caspase
cascade is necessary for induction of apoptosis by fibrillogenic amylin variants in two
pancreatic β-cell lines. Human amylin, as well as truncated 8–37 human amylin, evoked
sequential activation of caspases-8 and-3, and apoptosis, whereas non-β-sheet forming and
non-fibrillogenic homologs, such as [25, 28, 29 triprolyl] human amylin, did not, implying that …
development of type-2 diabetes. Here, we demonstrated that activation of a caspase
cascade is necessary for induction of apoptosis by fibrillogenic amylin variants in two
pancreatic β-cell lines. Human amylin, as well as truncated 8–37 human amylin, evoked
sequential activation of caspases-8 and-3, and apoptosis, whereas non-β-sheet forming and
non-fibrillogenic homologs, such as [25, 28, 29 triprolyl] human amylin, did not, implying that …