Morphine catalepsy in the rat: relation to striatal dopamine metabolism
K Kuschiski, O Hornykiewicz - European journal of pharmacology, 1972 - Elsevier
K Kuschiski, O Hornykiewicz
European journal of pharmacology, 1972•ElsevierIn rats morphine, like chlopromazine, produced catalepsy and raised striatal homovanillic
acid levels. Analysis of interactions between each of these cataleptogenic agents and
naloxone, 1-DOPA and apomorphine strongly suggests that morphine influences striatal
dopamine (DA) metabolism and produces catalepsy by a mechanism different from that of
chlorpromazine.
acid levels. Analysis of interactions between each of these cataleptogenic agents and
naloxone, 1-DOPA and apomorphine strongly suggests that morphine influences striatal
dopamine (DA) metabolism and produces catalepsy by a mechanism different from that of
chlorpromazine.
Abstract
In rats morphine, like chlopromazine, produced catalepsy and raised striatal homovanillic acid levels. Analysis of interactions between each of these cataleptogenic agents and naloxone, 1-DOPA and apomorphine strongly suggests that morphine influences striatal dopamine (DA) metabolism and produces catalepsy by a mechanism different from that of chlorpromazine.
Elsevier