MicroRNA biogenesis pathways in cancer

S Lin, RI Gregory - Nature reviews cancer, 2015 - nature.com
S Lin, RI Gregory
Nature reviews cancer, 2015nature.com
MicroRNAs (miRNAs) are critical regulators of gene expression. Amplification and
overexpression of individual'oncomiRs' or genetic loss of tumour suppressor miRNAs are
associated with human cancer and are sufficient to drive tumorigenesis in mouse models.
Furthermore, global miRNA depletion caused by genetic and epigenetic alterations in
components of the miRNA biogenesis machinery is oncogenic. This, together with the recent
identification of novel miRNA regulatory factors and pathways, highlights the importance of …
Abstract
MicroRNAs (miRNAs) are critical regulators of gene expression. Amplification and overexpression of individual 'oncomiRs' or genetic loss of tumour suppressor miRNAs are associated with human cancer and are sufficient to drive tumorigenesis in mouse models. Furthermore, global miRNA depletion caused by genetic and epigenetic alterations in components of the miRNA biogenesis machinery is oncogenic. This, together with the recent identification of novel miRNA regulatory factors and pathways, highlights the importance of miRNA dysregulation in cancer.
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